QuickView for NDUFS8 (gene)

Gene Symbol:

NDUFS8 Homo sapiens

Full name:

NADH:ubiquinone oxidoreductase core subunit S8

Synonyms:

CI-23k, CI23KD, TYKY, NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial, NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase), NADH-ubiquinone oxidoreductase 23 kDa subunit, complex I 23kDa subunit, complex I-23kD

Genomic Location:

Chr 11: 67554685-67560690

Description:

This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, ...

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This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  NFY_C ,  GCCATNTTG_YY1_Q6 ,  GGGNRMNNYCAT_UNKNOWN ,  SREBP_Q3 ,  GGCKCATGS_UNKNOWN ,  SF1_Q6

Cytogenetic Map:

11q13.2

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