QuickView for NECTIN4;jsessionid=AB906B5F2D86D41EAD484CA1FBCE3C5D (gene)

Gene Symbol:

NECTIN4 Homo sapiens

Full name:

nectin cell adhesion molecule 4

Synonyms:

EDSS1, LNIR, PRR4, PVRL4, nectin-4, nectin-4, Ig superfamily receptor LNIR, nectin 4, poliovirus receptor-related 4, poliovirus receptor-related protein 4

Genomic Location:

Chr 1: 159308120-159325966

Description:

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at t...

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This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA1_03 ,  AREB6_02 ,  GATA3_01 ,  GATA_Q6 ,  GCANCTGNY_MYOD_Q6 ,  CTTTGA_LEF1_Q2 ,  RFX1_01 ,  LEF1_Q2 ,  CACCCBINDINGFACTOR_Q6 ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  AREB6_03 ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

1q23.3

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