QuickView for NEDD4L;jsessionid=CB04978FB0DC8B5BD46DEB87AC215E6B (gene)

Gene Symbol:

NEDD4L Homo sapiens

Full name:

neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

Synonyms:

NEDD4-2, NEDD4.2, PVNH7, RSP5, hNEDD4-2, E3 ubiquitin-protein ligase NEDD4-like, HECT-type E3 ubiquitin transferase NED4L, ubiquitin-protein ligase Rsp5

Genomic Location:

Chr 18: 53862778-54216369

Description:

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a cri...

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This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  E12_Q6 ,  PAX4_04 ,  TTTGCAG_MIR518A2 ,  GCATTTG_MIR105 ,  TTANTCA_UNKNOWN ,  GCANCTGNY_MYOD_Q6 ,  AACTGGA_MIR145 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  STAT6_01 ,  CTTTGA_LEF1_Q2 ,  PBX1_01 ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  MYOD_Q6 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  STAT5A_03 ,  HMGIY_Q6 ,  GGCACTT_MIR519E ,  CCTGCTG_MIR214 ,  MYOGENIN_Q6 ,  GATA4_Q3 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  CACBINDINGPROTEIN_Q6 ,  AGGCACT_MIR5153P ,  PAX4_03 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

18q21.31

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