QuickView for NER (gene)
- Gene Symbol:
- NR1H2
Homo sapiens - Full name:
- nuclear receptor subfamily 1 group H member 2
- Synonyms:
- LXR-b, LXRB, NER, NER-I, RIP15, UNR, oxysterols receptor LXR-beta, LX receptor beta, liver X nuclear receptor beta, nuclear orphan receptor LXR-beta, nuclear receptor NER, steroid hormone-nuclear receptor NER, ubiquitously-expressed nuclear receptor
- Genomic Location:
- Chr 19: 55571497-55578079
- Description:
-
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lun...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
19q13.33
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | retinoic acid receptor binding | nuclear receptor activity | cation binding | hormone receptor binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | apolipoprotein A-I receptor binding | ATPase binding | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | retinoid X receptor binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | apolipoprotein receptor binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | nuclear receptor transcription coactivator activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | positive regulation of cellular component organization | response to lipopolysaccharide | regulation of cholesterol transport | regulation of localization | regulation of immune system process | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | positive regulation of protein secretion | regulation of response to interferon-gamma | regulation of lipid transport | hormone-mediated signaling pathway | negative regulation of proteolysis | retinoic acid receptor signaling pathway | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | negative regulation of signaling | positive regulation of cholesterol efflux | regulation of digestive system process | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | negative regulation of innate immune response | regulation of response to cytokine stimulus | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cholesterol storage | negative regulation of cellular metabolic process | positive regulation of pancreatic juice secretion | positive regulation of triglyceride biosynthetic process | regulation of cell differentiation | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | regulation of protein complex assembly | cellular response to molecule of bacterial origin | regulation of interferon-gamma-mediated signaling pathway | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of lipoprotein lipase activity | cellular lipid metabolic process | regulation of peptide secretion | response to stimulus | regulation of macrophage derived foam cell differentiation | regulation of fatty acid biosynthetic process | positive regulation of protein metabolic process | cellular nitrogen compound biosynthetic process | positive regulation of lipid biosynthetic process | sterol homeostasis | cholesterol homeostasis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | positive regulation of lipase activity | negative regulation of transport | cellular response to organic cyclic compound | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | regulation of peptide transport | cellular biosynthetic process | regulation of triglyceride metabolic process | regulation of lipid storage | positive regulation of high-density lipoprotein particle assembly | positive regulation of lipoprotein lipase activity | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | cellular response to hormone stimulus | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | positive regulation of secretion of lysosomal enzymes | negative regulation of cold-induced thermogenesis | regulation of catalytic activity | lipid metabolic process | regulation of gene expression | positive regulation of secretion | response to lipid | positive regulation of cellular metabolic process | negative regulation of lipid storage | regulation of nitrogen compound metabolic process | positive regulation of protein complex assembly | regulation of transcription by RNA polymerase II | positive regulation of lipid storage | positive regulation of digestive system process | positive regulation of hydrolase activity | regulation of high-density lipoprotein particle assembly | regulation of fatty acid metabolic process | positive regulation of cholesterol transport | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of immune response | positive regulation of fatty acid biosynthetic process | positive regulation of lipid localization | positive regulation of triglyceride lipase activity | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | homeostatic process | positive regulation of establishment of protein localization | regulation of cytokine-mediated signaling pathway | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of transport | regulation of lipid biosynthetic process | positive regulation of molecular function | negative regulation of interferon-gamma-mediated signaling pathway | negative regulation of lipid transport | positive regulation of triglyceride metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of establishment of protein localization | response to organic substance | regulation of innate immune response | positive regulation of fatty acid metabolic process | anatomical structure development | negative regulation of response to cytokine stimulus | negative regulation of endocytosis | metabolic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | nuclear receptor transcription coactivator activity | regulation of vesicle-mediated transport | chemical homeostasis | regulation of secretion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | negative regulation of pinocytosis | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | gene expression | regulation of protein secretion | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | positive regulation of protein transport | negative regulation of protein metabolic process | negative regulation of macrophage derived foam cell differentiation | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of endocytosis | cellular macromolecule biosynthetic process | response to biotic stimulus | regulation of cellular ketone metabolic process | regulation of developmental process | regulation of cholesterol efflux | developmental process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | negative regulation of cytokine-mediated signaling pathway | heterocycle metabolic process | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | positive regulation of lipid transport | cellular metabolic process | cellular response to organic substance | regulation of protein localization | response to steroid hormone | regulation of triglyceride biosynthetic process | lipid homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | response to other organism | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
