Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for NFATC2;jsessionid=375F4B89899BCD82D14BCA18AE82C5ED (gene)


Gene Symbol:
NFATC2 Homo sapiens Homo sapiens
Full name:
nuclear factor of activated T cells 2
Synonyms:
NFAT1, NFATP, nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFAT pre-existing subunit, NFAT transcription complex, preexisting component, T cell transcription factor NFAT1, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2, nuclear factor of activated T-cells, preexisting component, preexisting nuclear factor of activated T-cells 2
Genomic Location:
Chr 20: 49441172-49592665
Description:
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuc...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 20
20q13.2





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | phosphatase binding | heterocyclic compound binding

GO Biological Process

positive regulation of immune response | RNA metabolic process | transcription by RNA polymerase II | positive regulation of striated muscle cell differentiation | regulation of myoblast fusion | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | regulation of B cell activation | cell motility | immune response-regulating signaling pathway | intracellular signal transduction | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | striated muscle cell development | response to drug | inositol phosphate-mediated signaling | positive regulation of cellular biosynthetic process | cellular process | localization | regulation of syncytium formation by plasma membrane fusion | myotube cell development | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cell differentiation | positive regulation of muscle cell differentiation | muscle structure development | muscle cell differentiation | regulation of myotube differentiation | regulation of immune response | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of vasculature development | response to stimulus | muscle cell development | regulation of regulatory T cell differentiation | positive regulation of immune system process | response to stress | positive regulation of lymphocyte proliferation | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of B cell proliferation | positive regulation of cell activation | cellular nitrogen compound metabolic process | immune response-activating signal transduction | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | B cell receptor signaling pathway | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | locomotion | positive regulation of mononuclear cell proliferation | nitrogen compound metabolic process | cell migration | cellular response to DNA damage stimulus | regulation of T cell activation | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | regulation of lymphocyte activation | regulation of smooth muscle cell differentiation | regulation of nitrogen compound metabolic process | positive regulation of syncytium formation by plasma membrane fusion | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | Fc-epsilon receptor signaling pathway | positive regulation of cell differentiation | second-messenger-mediated signaling | negative regulation of smooth muscle cell differentiation | biosynthetic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | positive regulation of cell proliferation | regulation of RNA metabolic process | positive regulation of B cell activation | striated muscle cell differentiation | calcium-mediated signaling | cytokine production | activation of immune response | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of hemopoiesis | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of transcription, DNA-templated | positive regulation of myoblast fusion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | regulation of cell activation | regulation of striated muscle cell differentiation | calcineurin-mediated signaling | negative regulation of vascular smooth muscle cell differentiation | antigen receptor-mediated signaling pathway | calcineurin-NFAT signaling cascade | transcription, DNA-templated | signaling | regulation of transcription, DNA-templated | myotube differentiation | cell development | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | regulation of muscle cell differentiation | Fc receptor signaling pathway | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | regulation of B cell proliferation | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | negative regulation of muscle cell differentiation | positive regulation of metabolic process | immune system process | cellular metabolic process | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of myotube differentiation | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

nuclear transcription factor complex | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular