QuickView for NFKB2 (gene)

Gene Symbol:

NFKB2 Homo sapiens

Full name:

nuclear factor kappa B subunit 2

Synonyms:

CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52, nuclear factor NF-kappa-B p100 subunit, DNA-binding factor KBF2, NFKB, p52/p100 subunit, lymphocyte translocation chromosome 10 protein, nuclear factor Kappa-B, subunit 2, nuclear factor NF-kappa-B p52 subunit, nuclear factor of Kappa light chain gene enhancer in B cells 2, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100), oncogene Lyt-10, transcription factor NFKB2

Genomic Location:

Chr 10: 104144219-104152271

Description:

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on it...

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This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PU1_Q6 ,  MEIS1BHOXA9_01 ,  NFKAPPAB_01 ,  WHN_B ,  CREB_Q3 ,  NFKAPPAB65_01 ,  MYAATNNNNNNNGGC_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  GGGYGTGNY_UNKNOWN ,  GTGACGY_E4F1_Q6 ,  TEF1_Q6 ,  TST1_01 ,  GGGCGGR_SP1_Q6 ,  GCGNNANTTCC_UNKNOWN ,  SPZ1_01 ,  WGGAATGY_TEF1_Q6 ,  GATA4_Q3 ,  IK1_01 ,  SMAD4_Q6 ,  CREL_01 ,  NFKB_Q6_01 ,  AACTTT_UNKNOWN ,  NFKB_Q6 ,  NFKB_C ,  GGGNNTTTCC_NFKB_Q6_01

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Cytogenetic Map:

10q24.32

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