QuickView for NFKBIA;jsessionid=32444E29D3E7A0E8A9143E097ADF36E0 (gene)

Gene Symbol:

NFKBIA Homo sapiens

Full name:

NFKB inhibitor alpha

Synonyms:

IKBA, MAD-3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkappaBalpha, ikB-alpha, major histocompatibility complex enhancer-binding protein MAD3, nuclear factor of kappa light chain gene enhancer in B-cells, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Genomic Location:

Chr 14: 34940468-34943695

Description:

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediat...

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This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CTTGTAT_MIR381 ,  SP1_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  STAT6_01 ,  NFKAPPAB65_01 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  LFA1_Q6 ,  STAT5B_01 ,  TGCGCANK_UNKNOWN ,  NF1_Q6 ,  GGGCGGR_SP1_Q6 ,  CEBPB_02 ,  OCT1_03 ,  CCCNNGGGAR_OLF1_01 ,  NF1_Q6_01 ,  HMGIY_Q6 ,  CHOP_01 ,  CEBP_C ,  IK3_01 ,  CTGCAGY_UNKNOWN ,  CREL_01 ,  YWATTWNNRGCT_UNKNOWN ,  NFKB_Q6_01 ,  TAANNYSGCG_UNKNOWN ,  LXR_Q3 ,  P300_01 ,  AACTTT_UNKNOWN ,  ER_Q6 ,  DR4_Q2 ,  PAX2_02 ,  NFKB_Q6 ,  NFKB_C ,  PAX4_01 ,  GGGNNTTTCC_NFKB_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

14q13.2

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