QuickView for NHEJ1 (gene)

Gene Symbol:

NHEJ1 Homo sapiens

Full name:

non-homologous end joining factor 1

Synonyms:

XLF, non-homologous end-joining factor 1, XRCC4-like factor, nonhomologous end-joining factor 1, protein cernunnos

Genomic Location:

Chr 2: 219648292-219733767

Description:

Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorde...

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Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGCGGR_SP1_Q6

Cytogenetic Map:

2q35

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