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QuickView for NKCC2 (gene)


Gene Symbol:
SLC12A1 Homo sapiens Homo sapiens
Full name:
solute carrier family 12 member 1
Synonyms:
BSC1, NKCC2, solute carrier family 12 member 1, NKCC2A variant A, Na-K-2Cl cotransporter, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, kidney-specific Na-K-Cl symporter, solute carrier family 12 (sodium/potassium/chloride transporter), member 1, solute carrier family 12 (sodium/potassium/chloride transporters), member 1
Genomic Location:
Chr 15: 46285790-46383567
Description:
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 15
15q21.1





GO Molecular Function

anion transmembrane transporter activity | transmembrane transporter activity | potassium:chloride symporter activity | inorganic anion transmembrane transporter activity | symporter activity | chloride transmembrane transporter activity | sodium:potassium:chloride symporter activity | cation transmembrane transporter activity | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | sodium:chloride symporter activity | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | sodium ion transmembrane transporter activity | secondary active transmembrane transporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | cation:chloride symporter activity | solute:sodium symporter activity

GO Biological Process

establishment of localization | anion transmembrane transporter activity | cellular process | localization | cellular homeostasis | metal ion transport | anion transport | transmembrane transporter activity | cellular component organization | chloride transmembrane transport | chloride transport | potassium:chloride symporter activity | inorganic anion transport | regulation of cellular component size | inorganic anion transmembrane transporter activity | symporter activity | metal ion homeostasis | chloride transmembrane transporter activity | potassium ion import | sodium:potassium:chloride symporter activity | ion transmembrane transport | sodium ion transport | cation transmembrane transporter activity | monovalent inorganic cation transport | active transmembrane transporter activity | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | cation homeostasis | potassium ion homeostasis | homeostatic process | sodium:chloride symporter activity | cation transmembrane transport | metal ion transmembrane transporter activity | anion transmembrane transport | potassium ion transmembrane transporter activity | chemical homeostasis | sodium ion transmembrane transport | ion homeostasis | sodium ion transmembrane transporter activity | inorganic cation transmembrane transport | secondary active transmembrane transporter activity | transmembrane transport | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | regulation of cell size | cation transport | potassium ion transmembrane transport | cation:chloride symporter activity | ion transport | cell volume homeostasis | solute:sodium symporter activity

GO Cellular Component

integral component of membrane | apical plasma membrane | cell | intrinsic component of membrane | apical part of cell | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | membrane