Correlation Engine 2.0
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QuickView for NLGN3 (gene)


Gene Symbol:
NLGN3 Homo sapiens Homo sapiens
Full name:
neuroligin 3
Synonyms:
HNL3, neuroligin-3, gliotactin homolog
Genomic Location:
Chr X: 70281436-70307776
Description:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants e...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
RTAAACA_FREAC2_01 SMTTTTGT_UNKNOWN TFIIA_Q6 TGANTCA_AP1_C ZIC1_01 TGGNNNNNNKCCAR_UNKNOWN EFC_Q6 VDR_Q3 GATA3_01 HEN1_01
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr X
Xq13.1





GO Molecular Function

signaling receptor binding | neurexin family protein binding | signaling receptor activity | scaffold protein binding | cell adhesion molecule binding | protein binding

GO Biological Process

negative regulation of excitatory postsynaptic potential | response to radiation | cell morphogenesis | regulation of AMPA receptor activity | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | positive regulation of ion transmembrane transporter activity | regulation of cellular localization | regulation of synapse assembly | regulation of cell development | regulation of localization | establishment of localization | negative regulation of cellular process | positive regulation of developmental process | social behavior | cell differentiation | excitatory postsynaptic potential | negative regulation of dendrite development | positive regulation of signaling receptor activity | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of cation channel activity | generation of neurons | membrane organization | membrane biogenesis | neuron projection extension | positive regulation of neurological system process | cellular process | regulation of dendritic spine morphogenesis | localization | cell projection morphogenesis | positive regulation of synaptic transmission | regulation of respiratory gaseous exchange | negative regulation of signaling | developmental growth | visual learning | negative regulation of synapse organization | chemical synaptic transmission | neuron development | synapse assembly | learning | regulation of neuron projection development | establishment of localization in cell | regulation of terminal button organization | regulation of neurological system process | regulation of cell differentiation | regulation of cellular process | gliogenesis | cellular component organization | regulation of respiratory gaseous exchange by neurological system process | negative regulation of cell morphogenesis involved in differentiation | associative learning | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of long-term synaptic potentiation | negative regulation of neurological system process | negative regulation of dendritic spine morphogenesis | positive regulation of cation transmembrane transport | negative regulation of neuron projection development | postsynaptic membrane assembly | regulation of neurotransmitter receptor activity | cellular localization | cellular component assembly | regulation of synapse structure or activity | modulation of chemical synaptic transmission | presynaptic membrane assembly | positive regulation of synaptic transmission, glutamatergic | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of membrane potential | synaptic vesicle cycle | response to light stimulus | system development | regulation of signal transduction | modulation of excitatory postsynaptic potential | multicellular organism development | regulation of synaptic transmission, glutamatergic | negative regulation of dendritic spine development | learning or memory | neuron cell-cell adhesion | synaptic vesicle recycling | regulation of neuron differentiation | rhythmic synaptic transmission | regulation of postsynaptic membrane potential | axon development | nervous system process | membrane assembly | synaptic signaling | positive regulation of ion transmembrane transport | regulation of synapse organization | vesicle-mediated transport | synapse organization | axonogenesis | cognition | negative regulation of dendrite morphogenesis | glial cell differentiation | regulation of synaptic vesicle clustering | cell morphogenesis involved in differentiation | postsynapse assembly | cell communication | presynaptic membrane organization | synaptic vesicle endocytosis | regulation of respiratory system process | positive regulation of transporter activity | positive regulation of signal transduction | postsynaptic membrane organization | positive regulation of synapse assembly | positive regulation of transport | positive regulation of molecular function | neuron differentiation | presynapse assembly | regulation of signaling receptor activity | regulation of cell morphogenesis involved in differentiation | inhibitory postsynaptic potential | negative regulation of cell projection organization | visual behavior | import into cell | axon extension | anatomical structure development | developmental growth involved in morphogenesis | regulation of dendrite morphogenesis | cell surface receptor signaling pathway | cell projection organization | oligodendrocyte differentiation | endocytosis | behavior | cell adhesion | neuron projection development | vocalization behavior | positive regulation of cellular component biogenesis | positive regulation of ion transport | negative regulation of neuron differentiation | regulation of ion transmembrane transport | cell-cell adhesion | regulation of postsynapse organization | positive regulation of excitatory postsynaptic potential | adult behavior | regulation of dendrite development | regulation of cell communication | negative regulation of signal transduction | regulation of dendritic spine development | signaling | cell development | regulation of transmembrane transporter activity | positive regulation of synaptic vesicle clustering | regulation of ion transmembrane transporter activity | anatomical structure morphogenesis | regulation of NMDA receptor activity | regulation of nervous system development | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | developmental process | regulation of transport | developmental cell growth | regulation of cation channel activity | negative regulation of synaptic transmission | regulation of glutamate receptor signaling pathway | central nervous system development | positive regulation of AMPA receptor activity | regulation of synaptic plasticity | regulation of cell projection organization | positive regulation of glutamate receptor signaling pathway | long-term synaptic potentiation | negative regulation of cell development | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of neurogenesis | multicellular organismal process

GO Cellular Component

integral component of membrane | synapse | spanning component of membrane | cytoplasmic vesicle | symmetric synapse | cell | intrinsic component of membrane | synaptic membrane | cytoplasm | intracellular organelle | postsynaptic membrane | postsynapse | plasma membrane | vesicle | asymmetric synapse | integral component of postsynaptic membrane | integral component of plasma membrane | asymmetric, glutamatergic, excitatory synapse | membrane-bounded organelle | organelle | inhibitory synapse | glutamatergic synapse | cell periphery | excitatory synapse | GABA-ergic synapse | symmetric, GABA-ergic, inhibitory synapse | intracellular vesicle | cell surface | endocytic vesicle | intracellular | cell junction | membrane | intrinsic component of plasma membrane