QuickView for NLRP10;jsessionid=AACAFDC533D752A308470DC3D7264154 (gene)

Gene Symbol:

NLRP10 Homo sapiens

Full name:

NLR family pyrin domain containing 10

Synonyms:

CLR11.1, NALP10, NOD8, PAN5, PYNOD, NACHT, LRR and PYD domains-containing protein 10, NACHT, leucine rich repeat and PYD containing 10, nucleotide-binding oligomerization domain protein 8, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10

Genomic Location:

Chr 11: 7937732-7941635

Description:

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immun...

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Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT_Q6 ,  GR_Q6

Cytogenetic Map:

11p15.4

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