QuickView for NM23 (gene)
- Gene Symbol:
- NME1
Homo sapiens - Full name:
- NME/NM23 nucleoside diphosphate kinase 1
- Synonyms:
- AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1, nucleoside diphosphate kinase A, NDP kinase A, granzyme A-activated DNase, metastasis inhibition factor nm23, non-metastatic cells 1, protein (NM23A) expressed in, tumor metastatic process-associated protein
- Genomic Location:
- Chr 17: 46585919-46594449
- Description:
-
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding differ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
17q21.33
GO Molecular Function
ribosomal small subunit binding | nuclease activity | guanyl ribonucleotide binding | ribonucleoside binding | cation binding | magnesium ion binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | catalytic activity | ribonucleoprotein complex binding | ATP binding | anion binding | adenyl nucleotide binding | deoxyribonuclease activity | purine nucleotide binding | hydrolase activity, acting on ester bonds | identical protein binding | ion binding | nucleobase-containing compound kinase activity | organic cyclic compound binding | purine nucleoside binding | purine ribonucleoside triphosphate binding | nucleoside diphosphate kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | GTP binding | phosphotransferase activity, phosphate group as acceptor | transferase activity | nucleoside binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | guanyl nucleotide binding | small molecule binding | RNA binding
GO Biological Process
pyrimidine nucleoside biosynthetic process | purine ribonucleotide metabolic process | nuclease activity | pyrimidine nucleoside metabolic process | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | cell differentiation | positive regulation of epithelial cell proliferation | nervous system development | cellular process | localization | nucleotide metabolic process | ribose phosphate metabolic process | purine nucleotide biosynthetic process | UTP metabolic process | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | regulation of binding | regulation of cellular process | regulation of apoptotic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | CTP metabolic process | purine nucleotide metabolic process | pyrimidine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cellular nitrogen compound metabolic process | regulation of DNA binding | nucleic acid phosphodiester bond hydrolysis | carbohydrate derivative biosynthetic process | cellular biosynthetic process | purine nucleoside metabolic process | nucleotide biosynthetic process | system development | nitrogen compound metabolic process | multicellular organism development | phosphorus metabolic process | organophosphate metabolic process | nucleotide phosphorylation | nucleoside metabolic process | deoxyribonuclease activity | UTP biosynthetic process | small molecule metabolic process | vesicle-mediated transport | pyrimidine nucleotide biosynthetic process | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | phosphorylation | purine ribonucleotide biosynthetic process | nucleobase-containing compound kinase activity | nucleoside triphosphate biosynthetic process | pyrimidine ribonucleoside biosynthetic process | phosphate-containing compound metabolic process | GTP metabolic process | positive regulation of cell proliferation | nucleoside diphosphate kinase activity | positive regulation of molecular function | nucleobase-containing small molecule interconversion | nucleoside diphosphate metabolic process | DNA metabolic process | import into cell | CTP biosynthetic process | anatomical structure development | metabolic process | pyrimidine ribonucleotide biosynthetic process | endocytosis | nucleobase-containing compound metabolic process | organic substance metabolic process | positive regulation of binding | ribose phosphate biosynthetic process | positive regulation of DNA binding | regulation of epithelial cell proliferation | kinase activity | developmental process | carbohydrate derivative metabolic process | negative regulation of cell proliferation | heterocycle metabolic process | GTP biosynthetic process | cellular metabolic process | regulation of cell death | nucleoside diphosphate phosphorylation | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | ruffle | cell projection membrane | cell | ruffle membrane | cytoplasm | intracellular organelle | leading edge membrane | cell projection | plasma membrane | cell leading edge | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | cytosol | intracellular | membrane
