QuickView for NOG;jsessionid=E67AC4A221E7BD3706243AB3FA8CCE97 (gene)

Gene Symbol:

NOG Homo sapiens

Full name:

noggin

Synonyms:

SYM1, SYNS1, SYNS1A, noggin, symphalangism 1 (proximal)

Genomic Location:

Chr 17: 52026274-52027546

Description:

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in ...

View Full Description

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  PBX1_02 ,  HNF4ALPHA_Q6 ,  GTATTAT_MIR3693P ,  TTANTCA_UNKNOWN ,  GNCF_01 ,  FOXJ2_02 ,  NKX3A_01 ,  HP1SITEFACTOR_Q6 ,  WGTTNNNNNAAA_UNKNOWN ,  MEIS1BHOXA9_01 ,  AMEF2_Q6 ,  CTTTGA_LEF1_Q2 ,  GR_Q6_01 ,  CTAWWWATA_RSRFC4_Q2 ,  TGACCTY_ERR1_Q2 ,  TAAWWATAG_RSRFC4_Q2 ,  MEF2_02 ,  TATAAA_TATA_01 ,  CDPCR3HD_01 ,  GGGGCCC_MIR296 ,  GGATTA_PITX2_Q2 ,  FREAC3_01 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  GR_Q6 ,  CDPCR1_01 ,  GATA6_01 ,  NRF2_Q4 ,  RORA1_01 ,  MEIS1AHOXA9_01 ,  HAND1E47_01 ,  WGGAATGY_TEF1_Q6 ,  PIT1_Q6 ,  AFP1_Q6 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  MSX1_01 ,  IRF7_01 ,  TATA_01 ,  ZIC2_01 ,  T3R_Q6 ,  TBP_01 ,  ER_Q6_01 ,  MMEF2_Q6 ,  BRN2_01 ,  AACTTT_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  ERR1_Q2 ,  HNF1_Q6 ,  TATTATA_MIR374 ,  OLF1_01 ,  MEF2_Q6_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-374

Cytogenetic Map:

17q22

search → result