QuickView for NOT2 (gene)
- Gene Symbol:
- CNOT2
Homo sapiens - Full name:
- CCR4-NOT transcription complex subunit 2
- Synonyms:
- CDC36, HSPC131, NOT2, NOT2H, CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, negative regulator of transcription 2
- Genomic Location:
- Chr 12: 68923044-69035040
- Description:
-
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Saccharomyces cerevisiae , Macaca mulatta , Danio rerio , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
PR_Q2 , PAX4_04 , OCT1_04 , YATGNWAAT_OCT_C , STAT6_01 , TTF1_Q6 , TITF1_Q3 , STAT5A_03 , MEIS1_01 , MEIS1AHOXA9_01
- Cytogenetic Map:
-
12q15
GO Molecular Function
nuclease activity | 3'-5'-exoribonuclease activity | transcription corepressor binding | poly(A)-specific ribonuclease activity | exoribonuclease activity | hydrolase activity | ribonuclease activity | catalytic activity | hydrolase activity, acting on ester bonds | exoribonuclease activity, producing 5'-phosphomonoesters | protein binding | transcription factor binding | 3'-5' exonuclease activity | RNA polymerase II transcription corepressor binding | exonuclease activity | transcription cofactor binding | transcription coregulator activity
GO Biological Process
RNA metabolic process | gene silencing by RNA | regulation of cell cycle process | blastocyst formation | positive regulation of cellular component organization | intracellular signal transduction | regulation of cell cycle G1/S phase transition | nuclease activity | 3'-5'-exoribonuclease activity | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cell differentiation | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | regulation of organelle organization | cellular process | organic substance catabolic process | mitotic DNA integrity checkpoint | positive regulation of cytoplasmic mRNA processing body assembly | negative regulation of signaling | negative regulation of G1/S transition of mitotic cell cycle | negative regulation of nucleic acid-templated transcription | regulation of cell cycle | poly(A)-specific ribonuclease activity | negative regulation of cellular metabolic process | regulation of cellular process | gene silencing | regulation of metabolic process | catabolic process | regulation of protein complex assembly | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | mRNA catabolic process | exoribonuclease activity | response to stimulus | regulation of mitotic cell cycle phase transition | response to stress | regulation of intracellular steroid hormone receptor signaling pathway | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell cycle phase transition | cellular nitrogen compound metabolic process | regulation of stem cell population maintenance | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | mRNA metabolic process | ribonuclease activity | nuclear-transcribed mRNA catabolic process | cellular biosynthetic process | embryo development | nucleobase-containing compound catabolic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | multicellular organism development | positive regulation of organelle assembly | cellular response to DNA damage stimulus | regulation of intracellular estrogen receptor signaling pathway | trophectodermal cell differentiation | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cell cycle | RNA catabolic process | regulation of cell cycle arrest | regulation of nitrogen compound metabolic process | positive regulation of protein complex assembly | regulation of transcription by RNA polymerase II | nuclear-transcribed mRNA poly(A) tail shortening | negative regulation of intracellular steroid hormone receptor signaling pathway | biosynthetic process | exoribonuclease activity, producing 5'-phosphomonoesters | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | signal transduction involved in cell cycle checkpoint | mitotic G1 DNA damage checkpoint | chordate embryonic development | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | aromatic compound catabolic process | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | negative regulation of intracellular estrogen receptor signaling pathway | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | G1 DNA damage checkpoint | regulation of cytoplasmic mRNA processing body assembly | cellular macromolecule catabolic process | anatomical structure development | mitotic cell cycle | metabolic process | regulation of RNA biosynthetic process | 3'-5' exonuclease activity | negative regulation of transcription, DNA-templated | negative regulation of mitotic cell cycle | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | RNA phosphodiester bond hydrolysis | negative regulation of cellular protein metabolic process | gene expression | signal transduction involved in mitotic cell cycle checkpoint | negative regulation of translation | transcription, DNA-templated | blastocyst development | RNA phosphodiester bond hydrolysis, exonucleolytic | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | signal transduction involved in DNA damage checkpoint | regulation of developmental process | developmental process | positive regulation of cell cycle process | mitotic G1/S transition checkpoint | exonuclease activity | negative regulation of transcription by RNA polymerase II | transcription coregulator activity | heterocycle metabolic process | signal transduction involved in mitotic G1 DNA damage checkpoint | in utero embryonic development | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of organelle assembly | DNA damage checkpoint | regulation of translation | cell cycle checkpoint | signal transduction by p53 class mediator | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | regulation of cellular component organization | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | ribonucleoprotein granule | cytoplasm | intracellular organelle | P-body | protein-containing complex | plasma membrane | CCR4-NOT core complex | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | CCR4-NOT complex | cell periphery | cytosol | intracellular | membrane
