QuickView for NP2 (gene)

Gene Symbol:

NPTX2 Homo sapiens

Full name:

neuronal pentraxin 2

Synonyms:

NARP, NP-II, NP2, neuronal pentraxin-2, apexin, neuronal activity-regulated pentaxin, neuronal pentraxin II

Genomic Location:

Chr 7: 98084545-98097116

Description:

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-a...

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This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  CACTGTG_MIR128A_MIR128B ,  FXR_Q3 ,  TTANTCA_UNKNOWN ,  FOXJ2_02 ,  OCT1_04 ,  YATGNWAAT_OCT_C ,  YGTCCTTGR_UNKNOWN ,  YATTNATC_UNKNOWN ,  FXR_IR1_Q6 ,  TTAYRTAA_E4BP4_01 ,  TGACCTY_ERR1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  WTGAAAT_UNKNOWN ,  CAGGTG_E12_Q6 ,  E47_02 ,  CREBP1_01 ,  PITX2_Q2 ,  NFY_01 ,  GTGCCAA_MIR96 ,  OCT1_03 ,  MGGAAGTG_GABP_B ,  SOX5_01 ,  OCT1_06 ,  YCATTAA_UNKNOWN ,  OCT1_02 ,  POU3F2_02 ,  TTGTTT_FOXO4_01 ,  CART1_01 ,  TEF_Q6 ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  DR4_Q2 ,  TGACCTTG_SF1_Q6 ,  TATTATA_MIR374

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

7q22.1

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