QuickView for NR3C1 (gene)

Gene Symbol:

NR3C1 Homo sapiens

Full name:

nuclear receptor subfamily 3 group C member 1

Synonyms:

GCCR, GCR, GCRST, GR, GRL, glucocorticoid receptor, glucocorticoid nuclear receptor variant 1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Genomic Location:

Chr 5: 142637689-142795270

Description:

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding...

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This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  GTGCCAT_MIR183 ,  TGIF_01 ,  AAAGGGA_MIR204_MIR211 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  FOXO4_01 ,  AP2GAMMA_01 ,  TAGCTTT_MIR9 ,  AP2ALPHA_01 ,  GATA1_04 ,  TGTATGA_MIR4853P ,  GGGYGTGNY_UNKNOWN ,  GCACCTT_MIR18A_MIR18B ,  RP58_01 ,  CEBP_01 ,  CAGGTG_E12_Q6 ,  CAGNYGKNAAA_UNKNOWN ,  TGCCTTA_MIR124A ,  LMO2COM_02 ,  YKACATTT_UNKNOWN ,  E4F1_Q6 ,  AHR_Q5 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  ACTGCAG_MIR173P ,  TCCAGAT_MIR5165P ,  AP2_Q3 ,  ATACTGT_MIR144 ,  AHRARNT_01 ,  AGGGCCA_MIR328 ,  AHR_01 ,  RNGTGGGC_UNKNOWN ,  GTGCCTT_MIR506 ,  GGCAGCT_MIR22 ,  TTGTTT_FOXO4_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  GTGTCAA_MIR514 ,  GATA1_05 ,  GTTATAT_MIR410 ,  CREB_Q2 ,  GTGGGTGK_UNKNOWN ,  TCCATTKW_UNKNOWN ,  NFKB_Q6_01 ,  AAACCAC_MIR140 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  ACCTGTTG_UNKNOWN ,  FOXO4_02 ,  TATTATA_MIR374 ,  CCACACA_MIR147 ,  GGGTGGRR_PAX4_03 ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

5q31.3

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