QuickView for NRAMP (gene)

Gene Symbol:

SLC11A1 Homo sapiens

Full name:

solute carrier family 11 member 1

Synonyms:

LSH, NRAMP, NRAMP1, natural resistance-associated macrophage protein 1, NRAMP 1, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, solute carrier family 11 (sodium/phosphate symporters), member 1

Genomic Location:

Chr 2: 218954996-218969861

Description:

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associat...

View Full Description

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  NFE2_01 ,  AP1_Q6_01 ,  AP1_01 ,  NRF2_Q4 ,  TCF11MAFG_01

Cytogenetic Map:

2q35

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