QuickView for NRL;jsessionid=AEFEA19F5F207BCFC5ACCFA719C710D5 (gene)
- Gene Symbol:
- NRL
Homo sapiens - Full name:
- neural retina leucine zipper
- Synonyms:
- D14S46E, NRL-MAF, RP27, neural retina-specific leucine zipper protein, neural retinal-specific leucine zipper
- Genomic Location:
- Chr 14: 23619156-23623672
- Description:
-
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
OCT1_05 , OCT1_B , OCT1_01 , YATGNWAAT_OCT_C , OCT_Q6 , OCT1_Q5_01 , OCT_C , OCT1_Q6 , ATGCTGG_MIR338 , ALPHACP1_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
14q11.2-q12
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | protein domain specific binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | leucine zipper domain binding | LRR domain binding | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | eye development | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cell differentiation | nervous system development | neurogenesis | generation of neurons | positive regulation of cellular biosynthetic process | cellular process | neuron development | positive regulation of nitrogen compound metabolic process | retinal rod cell development | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | positive regulation of rhodopsin gene expression | response to stimulus | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of RNA biosynthetic process | cellular biosynthetic process | eye photoreceptor cell differentiation | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | nervous system process | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | sensory organ development | regulation of cellular metabolic process | eye morphogenesis | transcription coactivator activity | regulation of RNA metabolic process | eye photoreceptor cell development | regulation of rhodopsin gene expression | neuron differentiation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | anatomical structure development | metabolic process | visual perception | regulation of RNA biosynthetic process | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | sensory perception of light stimulus | gene expression | transcription, DNA-templated | sensory perception | regulation of transcription, DNA-templated | cell development | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | developmental process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | photoreceptor cell development | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | photoreceptor cell differentiation | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
