QuickView for NRXN2;jsessionid=CCECCECB550BB2F9A61668FC6CE8BDB9 (gene)

Gene Symbol:

NRXN2 Homo sapiens

Full name:

neurexin 2

Synonyms:

neurexin-2-beta, neurexin II

Genomic Location:

Chr 11: 64130222-64247236

Description:

This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are pr...

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This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  CGCAAAA_MIR450 ,  TGANNYRGCA_TCF11MAFG_01 ,  GCANCTGNY_MYOD_Q6 ,  ATF4_Q2 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  CAGGTA_AREB6_01 ,  AP1FJ_Q2 ,  NF1_Q6 ,  GCAAAAA_MIR129 ,  AREB6_01 ,  NF1_Q6_01 ,  NRF2_Q4 ,  AP1_Q2 ,  TGACCTTG_SF1_Q6 ,  TCCAGAG_MIR518C ,  SF1_Q6 ,  TCF11MAFG_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

11q13.1

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