QuickView for NUP153;jsessionid=D132FB758B740886817034850743C961 (gene)

Gene Symbol:

NUP153 Homo sapiens

Full name:

nucleoporin 153

Synonyms:

HNUP153, N153, nuclear pore complex protein Nup153, 153 kDa nucleoporin, nuclear pore complex protein hnup153, nucleoporin 153kD, nucleoporin 153kDa, nucleoporin Nup153

Genomic Location:

Chr 6: 17723248-17814797

Description:

Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylg...

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Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GABP_B ,  AAGCCAT_MIR135A_MIR135B ,  E2F1_Q4_01 ,  CACGTG_MYC_Q2 ,  TGTGTGA_MIR377 ,  GTGACTT_MIR224 ,  TCTGATC_MIR383 ,  E2F1_Q4 ,  TCTGATA_MIR361 ,  E2F_Q6 ,  TTCYRGAA_UNKNOWN ,  E2F_Q4 ,  AACYNNNNTTCCS_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  ATGTTAA_MIR302C ,  TAGAACC_MIR182 ,  ACTAYRNNNCCCR_UNKNOWN ,  E2F_03 ,  NCX_01 ,  NMYC_01 ,  CEBP_C ,  GTCNYYATGR_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  GKCGCNNNNNNNTGAYG_UNKNOWN ,  GTGGTGA_MIR197 ,  E2F_Q3 ,  E2F_Q3_01 ,  NFKB_C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-383 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-496

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Cytogenetic Map:

6p22.3

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