QuickView for NXF3 (gene)

Gene Symbol:

NXF3 Homo sapiens

Full name:

nuclear RNA export factor 3

Synonyms:

nuclear RNA export factor 3, TAP-like protein 3, TAPL-3

Genomic Location:

Chr X: 102217405-102234678

Description:

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain...

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This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AGCYRWTTC_UNKNOWN ,  FOXD3_01 ,  AREB6_04 ,  WGTTNNNNNAAA_UNKNOWN ,  YCATTAA_UNKNOWN ,  TTGTTT_FOXO4_01 ,  AACTTT_UNKNOWN

Cytogenetic Map:

Xq22.1

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