QuickView for Nek11 (gene)
- Gene Symbol:
- NEK11
Homo sapiens - Full name:
- NIMA related kinase 11
- Synonyms:
- serine/threonine-protein kinase Nek11, NIMA (never in mitosis gene a)- related kinase 11
- Genomic Location:
- Chr 3: 132228417-132551993
- Description:
-
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
3q22.1
GO Molecular Function
cation binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
intra-S DNA damage checkpoint | regulation of cell cycle process | intracellular signal transduction | negative regulation of cellular process | histone modification | cellular process | chromatin organization | mitotic DNA integrity checkpoint | regulation of cell cycle | regulation of cellular process | cellular component organization | response to stimulus | regulation of mitotic cell cycle phase transition | response to stress | regulation of cell cycle phase transition | protein serine/threonine kinase activity | protein modification process | macromolecule modification | nitrogen compound metabolic process | mitotic DNA damage checkpoint | phosphorus metabolic process | cellular response to DNA damage stimulus | cellular response to stress | cell cycle | phosphorylation | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | histone phosphorylation | regulation of mitotic cell cycle | protein metabolic process | mitotic cell cycle | metabolic process | negative regulation of mitotic cell cycle | protein kinase activity | organic substance metabolic process | negative regulation of cell cycle | signaling | covalent chromatin modification | cellular protein metabolic process | kinase activity | organelle organization | cellular protein modification process | cell cycle phase transition | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | DNA damage checkpoint | cell cycle checkpoint | signal transduction | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
