QuickView for Nek1 (gene)
- Gene Symbol:
- NEK1
Homo sapiens - Full name:
- NIMA related kinase 1
- Synonyms:
- NY-REN-55, SRPS2, SRPS2A, SRTD6, serine/threonine-protein kinase Nek1, NIMA (never in mitosis gene a)-related kinase 1, never in mitosis A-related kinase 1, nimA-related protein kinase 1, protein-serine/threonine kinase, renal carcinoma antigen NY-REN-55
- Genomic Location:
- Chr 4: 170551004-170770189
- Description:
-
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms hav...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
4q33
GO Molecular Function
cation binding | 14-3-3 protein binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
detection of stimulus | intracellular signal transduction | peptidyl-amino acid modification | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | cellular process | positive regulation of protein kinase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | positive regulation of cellular protein metabolic process | cellular component organization | response to stimulus | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | protein serine/threonine kinase activity | cellular component assembly | protein modification process | macromolecule modification | activation of protein kinase activity | stress-activated protein kinase signaling cascade | organelle assembly | nitrogen compound metabolic process | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of phosphorylation | cellular response to stress | cell cycle | cell projection assembly | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | cell division | regulation of cellular protein metabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | regulation of protein phosphorylation | protein tyrosine kinase activity | positive regulation of molecular function | protein metabolic process | positive regulation of protein modification process | regulation of kinase activity | DNA damage response, detection of DNA damage | cell projection organization | metabolic process | protein kinase activity | organic substance metabolic process | cilium assembly | positive regulation of kinase activity | regulation of phosphate metabolic process | cilium organization | signaling | positive regulation of phosphorylation | cellular protein metabolic process | kinase activity | organelle organization | cellular protein modification process | positive regulation of metabolic process | cellular metabolic process | signal transduction | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
pericentriolar material | intracellular membrane-bounded organelle | microtubule organizing center | cell | cytoplasm | intracellular organelle | centrosome | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | cytoskeleton | intracellular
