QuickView for Neurexin (biogroup)

Description:: Neurexins (NRXNs) are presynaptic transmembrane proteins with a major role in cell-cell interactions across the synapse. There are three NRXNs genes (NRXN 1-3) in vertebrates, each of which has both an upstream promoter that is used to generate the larger alpha-NRXNs and a downstream promoter that is used to generate the shorter beta-NRXNs. Alpha-neurexins (I alpha, II alpha, and III alpha) and beta-neurexins (I beta and II beta) have identical C termini but distinct N termini. Alpha-neurexins contain five LNS and three EGF domains at the N terminus that are absent from beta-neurexins.

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