QuickView for Nr4a3 (gene)

Gene Symbol:

NR4A3 Homo sapiens

Full name:

nuclear receptor subfamily 4 group A member 3

Synonyms:

CHN, CSMF, MINOR, NOR1, TEC, nuclear receptor subfamily 4 group A member 3, chondrosarcoma, extraskeletal myxoid, fused to EWS, mitogen-induced nuclear orphan receptor, neuron-derived orphan receptor 1, nuclear hormone receptor NOR-1, translocated in extraskeletal chondrosarcoma

Genomic Location:

Chr 9: 101623958-101668994

Description:

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gen...

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This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  ACAACCT_MIR453 ,  PR_Q2 ,  HNF4ALPHA_Q6 ,  OCT1_05 ,  SMTTTTGT_UNKNOWN ,  ATGCACG_MIR517B ,  HNF3ALPHA_Q6 ,  TGIF_01 ,  RYTTCCTG_ETS2_B ,  FOX_Q2 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  HFH3_01 ,  NFAT_Q6 ,  VDR_Q3 ,  TGANNYRGCA_TCF11MAFG_01 ,  ATGTCAC_MIR489 ,  HEN1_01 ,  YATGNWAAT_OCT_C ,  SYATTGTG_UNKNOWN ,  CACGTG_MYC_Q2 ,  ATTACAT_MIR3803P ,  TTCNRGNNNNTTC_HSF_Q6 ,  GCANCTGNY_MYOD_Q6 ,  AAAYWAACM_HFH4_01 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  ATF4_Q2 ,  XBP1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  TAGCTTT_MIR9 ,  E2F_01 ,  CTTTGA_LEF1_Q2 ,  TTF1_Q6 ,  GTGCAAA_MIR507 ,  COUP_01 ,  CREB_Q4 ,  WHN_B ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  TCF4_Q5 ,  COMP1_01 ,  HNF4_DR1_Q3 ,  CTTTGTA_MIR524 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  CREBP1_Q2 ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  DBP_Q6 ,  TAATGTG_MIR323 ,  TGCAAAC_MIR452 ,  GGGYGTGNY_UNKNOWN ,  CATTTCA_MIR203 ,  GTGACGY_E4F1_Q6 ,  YYCATTCAWW_UNKNOWN ,  CEBP_01 ,  GCTCTTG_MIR335 ,  P53_02 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  DR1_Q3 ,  TNCATNTCCYR_UNKNOWN ,  HSF1_01 ,  CACCAGC_MIR138 ,  AGCTCCT_MIR28 ,  PXR_Q2 ,  TST1_01 ,  HNF3_Q6 ,  GTCTTCC_MIR7 ,  RRAGTTGT_UNKNOWN ,  MYOD_Q6 ,  CREB_02 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  GTGCCAA_MIR96 ,  GCAAGAC_MIR431 ,  OCT1_03 ,  E4F1_Q6 ,  E2F1_Q3_01 ,  NKX61_01 ,  NKX25_02 ,  E47_01 ,  HFH4_01 ,  TGTTTGY_HNF3_Q6 ,  HSF2_01 ,  PTF1BETA_Q6 ,  STAT_01 ,  AREB6_03 ,  RNGTGGGC_UNKNOWN ,  GTGCCTT_MIR506 ,  EN1_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  HEN1_02 ,  IRF7_01 ,  CREB_Q2 ,  IK1_01 ,  COUP_DR1_Q6 ,  TGCTTTG_MIR330 ,  GTGGGTGK_UNKNOWN ,  TTCYNRGAA_STAT5B_01 ,  TACAATC_MIR508 ,  AAGCACT_MIR520F ,  TCCATTKW_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  STAT5A_01 ,  AAAGGAT_MIR501 ,  PAX3_B ,  CAGCTG_AP4_Q5 ,  CACBINDINGPROTEIN_Q6 ,  SRY_02 ,  BRN2_01 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  PPAR_DR1_Q2 ,  ACAGGGT_MIR10A_MIR10B ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  COREBINDINGFACTOR_Q6 ,  GTTNYYNNGGTNA_UNKNOWN ,  ACCATTT_MIR522 ,  GTTRYCATRR_UNKNOWN ,  PAX4_01 ,  CACTTTG_MIR520G_MIR520H ,  TATTATA_MIR374 ,  GGGTGGRR_PAX4_03 ,  TAXCREB_01 ,  STAT5A_02 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-431 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-500 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

9q31.1

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