QuickView for Nrcam (gene)

Gene Symbol:

NRCAM Homo sapiens

Full name:

neuronal cell adhesion molecule

Synonyms:

neuronal cell adhesion molecule, NgCAM-related cell adhesion molecule, neuronal surface protein Bravo

Genomic Location:

Chr 7: 107575318-107884062

Description:

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This ge...

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Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTCCGTT_MIR191 ,  EGR2_01 ,  LEF1_Q6 ,  CAGGTG_E12_Q6 ,  GCAAGAC_MIR431 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  RNGTGGGC_UNKNOWN ,  GTGCCTT_MIR506 ,  TTGCCAA_MIR182 ,  CTTTGT_LEF1_Q2

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-191 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-431 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

7q31.1

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