QuickView for Nuclear receptor coactivator (biogroup)

Description:: This group represents the nuclear receptor coactivator family, also known as the SRC/p160 nuclear receptor coactivator family, which contains proteins that are ligand-dependent transcription factors. These receptors can function as molecular switches. NCOA1 directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. It is involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). It is also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. It plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. It can be regulated by sumoylation and ubiquitination. NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Together with NCOA1, it is required to control energy balance between white and brown adipose tissues. NCOA3 is overexpressed in a fraction of breast cancers and has been linked to prognosis and tamoxifen resistance.

3 features