QuickView for OAS3;jsessionid=E96027BAEC4696B5E5485CAC05F0B04E (gene)
- Gene Symbol:
- OAS3
Homo sapiens - Full name:
- 2'-5'-oligoadenylate synthetase 3
- Synonyms:
- p100, p100OAS, 2'-5'-oligoadenylate synthase 3, (2-5')oligo(A) synthase 3, (2-5')oligo(A) synthetase 3, 2'-5'-oligoadenylate synthetase 3, 100kDa, 2'-5'oligoadenylate synthetase p100, 2-5A synthase 3, 2-5A synthetase 3, p100 OAS
- Genomic Location:
- Chr 12: 111860632-111895437
- Description:
-
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
12q24.13
GO Molecular Function
cation binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | nucleotidyltransferase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | adenylyltransferase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | 2'-5'-oligoadenylate synthetase activity | drug binding | metal ion binding | heterocyclic compound binding | small molecule binding | RNA binding | double-stranded RNA binding
GO Biological Process
response to virus | response to cytokine | cellular response to type I interferon | defense response to other organism | defense response | cellular process | response to type I interferon | negative regulation of viral life cycle | regulation of cellular process | regulation of metabolic process | interferon-gamma-mediated signaling pathway | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular response to interferon-gamma | response to stimulus | response to stress | cellular nitrogen compound metabolic process | negative regulation of viral genome replication | response to external biotic stimulus | nitrogen compound metabolic process | regulation of catalytic activity | defense response to virus | regulation of nitrogen compound metabolic process | cytokine-mediated signaling pathway | negative regulation of viral process | cellular response to cytokine stimulus | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | regulation of viral process | response to organic substance | cell surface receptor signaling pathway | metabolic process | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of ribonuclease activity | response to interferon-gamma | type I interferon signaling pathway | signaling | response to biotic stimulus | innate immune response | heterocycle metabolic process | immune system process | cellular metabolic process | regulation of viral genome replication | cellular response to organic substance | regulation of viral life cycle | response to other organism | signal transduction
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | plasma membrane | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane
