QuickView for ODF2 (gene)

Gene Symbol:

ODF2 Homo sapiens

Full name:

outer dense fiber of sperm tails 2

Synonyms:

CT134, ODF2/1, ODF2/2, ODF84, outer dense fiber protein 2, cancer/testis antigen 134, cenexin 1, outer dense fiber of sperm tails, 84-kD, sperm tail structural protein, testis tissue sperm-binding protein Li 51e

Genomic Location:

Chr 9: 130258253-130303060

Description:

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibe...

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The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  CMYB_01 ,  WGTTNNNNNAAA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  AGGAGTG_MIR483 ,  MYB_Q5_01 ,  GGGAGGRR_MAZ_Q6 ,  LEF1_Q6 ,  GTGACGY_E4F1_Q6 ,  ZID_01 ,  GGGCGGR_SP1_Q6 ,  PITX2_Q2 ,  NFY_01 ,  WCTCNATGGY_UNKNOWN ,  RNGTGGGC_UNKNOWN ,  MYB_Q6 ,  MEIS1AHOXA9_01 ,  SCGGAAGY_ELK1_02 ,  GTCNYYATGR_UNKNOWN ,  YY1_02 ,  RTTTNNNYTGGM_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  GGGTGGRR_PAX4_03 ,  MYB_Q3

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Cytogenetic Map:

9q34.11

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