QuickView for OGG1 (gene)

Gene Symbol:

OGG1 Homo sapiens

Full name:

8-oxoguanine DNA glycosylase

Synonyms:

HMMH, HOGG1, MUTM, OGH1, N-glycosylase/DNA lyase, 8-hydroxyguanine DNA glycosylase, AP lyase, DNA-apurinic or apyrimidinic site lyase, OGG1 type 1f

Genomic Location:

Chr 3: 9765705-9783342

Description:

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and t...

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This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  FREAC7_01 ,  NFY_C ,  TEL2_Q6 ,  CTTTGA_LEF1_Q2 ,  MAF_Q6 ,  TCF4_Q5 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  CDP_02 ,  PAX4_02 ,  STAT5B_01 ,  NKX62_Q2 ,  AACYNNNNTTCCS_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  NRF2_Q4 ,  RNGTGGGC_UNKNOWN ,  CETS1P54_01 ,  TAATTA_CHX10_01 ,  CART1_01 ,  SCGGAAGY_ELK1_02 ,  ZIC2_01 ,  TTCYNRGAA_STAT5B_01 ,  STAT5A_01 ,  CAGCTG_AP4_Q5 ,  ELK1_02 ,  FOXM1_01 ,  YNGTTNNNATT_UNKNOWN ,  NFKB_Q6 ,  HNF6_Q6 ,  RACTNNRTTTNC_UNKNOWN

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Cytogenetic Map:

3p25.3

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