QuickView for OGT;jsessionid=8C5A12C856411C53B9E42A497A6A36D3 (gene)

Gene Symbol:

OGT Homo sapiens

Full name:

O-linked N-acetylglucosamine (GlcNAc) transferase

Synonyms:

HINCUT-1, HRNT1, MRX106, O-GLCNAC, OGT1, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, O-GlcNAc transferase p110 subunit, O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase), O-linked N-acetylglucosamine transferase 110 kDa subunit, UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase, uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase

Genomic Location:

Chr X: 70669658-70712465

Description:

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sit...

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This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  ATGCAGT_MIR217 ,  GTGCCAT_MIR183 ,  TTTGCAC_MIR19A_MIR19B ,  TAL1ALPHAE47_01 ,  GCATTTG_MIR105 ,  CCCAGAG_MIR326 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CACGTG_MYC_Q2 ,  E4BP4_01 ,  GCAAGGA_MIR502 ,  CCAGGTT_MIR490 ,  GAGACTG_MIR452 ,  CAGTGTT_MIR141_MIR200A ,  GTACTGT_MIR101 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  ZIC3_01 ,  AGGAGTG_MIR483 ,  AAGCAAT_MIR137 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  WTGAAAT_UNKNOWN ,  RGAANNTTC_HSF1_01 ,  RYTGCNWTGGNR_UNKNOWN ,  ACATTCC_MIR1_MIR206 ,  GGGYGTGNY_UNKNOWN ,  CCTGTGA_MIR513 ,  GGCAGAC_MIR346 ,  GTCAGGA_MIR378 ,  CAGCTTT_MIR320 ,  GTCTTCC_MIR7 ,  CTCAAGA_MIR526B ,  CAGGGTC_MIR504 ,  TGCCTTA_MIR124A ,  GTTTGTT_MIR495 ,  ATGCTGC_MIR103_MIR107 ,  GGGCGGR_SP1_Q6 ,  ATGTTTC_MIR494 ,  GTGCCAA_MIR96 ,  S8_01 ,  CTCTGGA_MIR520A_MIR525 ,  TAATAAT_MIR126 ,  AGGTGCA_MIR500 ,  ACTGCAG_MIR173P ,  TGTTTGY_HNF3_Q6 ,  CAGCAGG_MIR370 ,  KCCGNSWTTT_UNKNOWN ,  TTGCCAA_MIR182 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  AACATTC_MIR4093P ,  TTGTTT_FOXO4_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  RTTTNNNYTGGM_UNKNOWN ,  AGCGCAG_MIR191 ,  CTGAGCC_MIR24 ,  ATAACCT_MIR154 ,  ZIC2_01 ,  TGCTTTG_MIR330 ,  AGGGCAG_MIR18A ,  T3R_Q6 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CTTTGT_LEF1_Q2 ,  AGGCACT_MIR5153P ,  AAACCAC_MIR140 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  GGARNTKYCCA_UNKNOWN ,  CAATGCA_MIR33 ,  AGGAAGC_MIR5163P ,  ATGTAGC_MIR221_MIR222 ,  AACGGTT_MIR451

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-346 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-451 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-490 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-500 ,  Predicted Gene Targets for miR-504 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-543 ,  Predicted Gene Targets for miR-544

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Cytogenetic Map:

Xq13.1

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