QuickView for OPRPN (gene)

Gene Symbol:

OPRPN Homo sapiens

Full name:

opiorphin prepropeptide

Synonyms:

BPLP, PRL1, PROL1, opiorphin, opiorphin prepropeptide, basic proline-rich lacrimal protein, basic proline-rich protein, proline rich, lacrimal 1, proline-rich 1, proline-rich protein 1

Genomic Location:

Chr 4: 71298188-71310503

Description:

This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptid...

View Full Description

This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants.

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Orthologs:

Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTCYNRGAA_STAT5B_01

Cytogenetic Map:

4q13.3

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