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QuickView for P38gamma (gene)


Gene Symbol:
MAPK12 Homo sapiens Homo sapiens
Full name:
mitogen-activated protein kinase 12
Synonyms:
ERK-6, ERK3, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3, mitogen-activated protein kinase 12, MAP kinase 12, MAP kinase p38 gamma, extracellular signal-regulated kinase 6, mitogen-activated protein kinase 3, mitogen-activated protein kinase p38 gamma, stress-activated protein kinase 3
Genomic Location:
Chr 22: 49033458-49042216
Description:
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Canis lupus familiaris Pan troglodytes Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 22
22q13.33





GO Molecular Function

cation binding | magnesium ion binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | MAP kinase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

RNA metabolic process | intracellular signal transduction | peptidyl-amino acid modification | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | cellular process | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | positive regulation of muscle cell differentiation | muscle structure development | DNA damage induced protein phosphorylation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | MAPK cascade | response to stimulus | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | response to stress | cellular nitrogen compound biosynthetic process | protein serine/threonine kinase activity | positive regulation of proteolysis | cellular nitrogen compound metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | regulation of peptidase activity | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of gene expression | cellular response to stress | cell cycle | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | positive regulation of hydrolase activity | positive regulation of cell differentiation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | MAP kinase activity | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of RNA metabolic process | positive regulation of molecular function | protein metabolic process | response to organic substance | cell cycle arrest | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | animal organ development | gene expression | transcription, DNA-templated | negative regulation of cell cycle | signaling | regulation of transcription, DNA-templated | myoblast differentiation | cellular protein metabolic process | cellular macromolecule biosynthetic process | regulation of developmental process | kinase activity | developmental process | regulation of muscle cell differentiation | peptidyl-serine phosphorylation | cellular protein modification process | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | muscle organ development | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular