QuickView for PAF receptor (gene)
- Gene Symbol:
- Ptafr
Mus musculus - Full name:
- platelet-activating factor receptor
- Synonyms:
- PAFR, platelet-activating factor receptor, PAF receptor
- Genomic Location:
- Chr 4: 132119982-132136781
- Description:
-
This gene encodes a member of the G-protein coupled receptor 1 family of proteins. Binding of the encoded protein to its phospholipid ligand, platelet-activating factor (PAF), may regulate the inflammatory response and the perception of pain. Homozygous knockout mice for this gene exhibit impaired anaphylactic response, resistance to bacterial infe...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
kinase binding | protein kinase binding | transmembrane signaling receptor activity | enzyme binding | mitogen-activated protein kinase binding | lipid binding | G-protein coupled purinergic nucleotide receptor activity | G-protein coupled receptor activity | carbohydrate derivative binding | phospholipid binding | anion binding | signaling receptor activity | ion binding | platelet activating factor receptor activity | signaling pattern recognition receptor activity | protein binding | lipopolysaccharide receptor activity | lipopolysaccharide binding | purinergic nucleotide receptor activity
GO Biological Process
positive regulation of immune response | positive regulation of smooth muscle cell proliferation | regulation of blood vessel diameter | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | positive regulation of leukocyte adhesion to vascular endothelial cell | positive regulation of blood circulation | inositol trisphosphate biosynthetic process | positive regulation of leukocyte tethering or rolling | positive regulation of ion transmembrane transporter activity | immune response-regulating signaling pathway | response to lipopolysaccharide | intracellular signal transduction | regulation of localization | regulation of carbohydrate metabolic process | establishment of localization | regulation of immune system process | positive regulation of maternal process involved in parturition | purinergic nucleotide receptor signaling pathway | defense response | regulation of smooth muscle contraction | regulation of inositol phosphate biosynthetic process | polyol metabolic process | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | positive regulation of sensory perception of pain | regulation of neutrophil degranulation | innate immune response-activating signal transduction | positive regulation of neurological system process | positive regulation of cellular biosynthetic process | cellular process | regulation of cytokine biosynthetic process | regulation of cell motility | localization | positive regulation of immune effector process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neurological system process | positive regulation of vasoconstriction | regulation of immune response | regulation of cellular process | parturition | cellular response to lipid | regulation of metabolic process | cellular response to molecule of bacterial origin | regulation of cellular extravasation | positive regulation of translation | positive regulation of cellular protein metabolic process | G-protein coupled purinergic nucleotide receptor activity | positive regulation of tumor necrosis factor production | G-protein coupled receptor activity | response to stimulus | regulation of chloride transport | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of blood vessel size | response to stress | posttranscriptional regulation of gene expression | alcohol metabolic process | regulation of cell proliferation | regulation of blood circulation | positive regulation of cell-cell adhesion | phosphatidylinositol-mediated signaling | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | activation of innate immune response | reproduction | response to molecule of bacterial origin | G-protein coupled purinergic nucleotide receptor signaling pathway | positive regulation of lipase activity | immune response-activating signal transduction | blood circulation | G-protein coupled receptor signaling pathway | regulation of cell adhesion | negative regulation of blood pressure | regulation of nucleic acid-templated transcription | positive regulation of exocytosis | locomotion | organic hydroxy compound metabolic process | positive regulation of phospholipase C activity | response to external biotic stimulus | reproductive process | pattern recognition receptor signaling pathway | phosphorus metabolic process | regulation of muscle contraction | regulation of catalytic activity | regulation of sensory perception of pain | transcytosis | positive regulation of neutrophil degranulation | regulation of gene expression | positive regulation of secretion | response to lipid | regulation of blood pressure | organophosphate metabolic process | positive regulation of cellular metabolic process | regulation of anion channel activity | positive regulation of ion transmembrane transport | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | regulation of interleukin-6 biosynthetic process | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | positive regulation of cell migration | positive regulation of voltage-gated chloride channel activity | biosynthetic process | regulation of cellular protein metabolic process | regulation of phospholipase activity | inositol lipid-mediated signaling | regulation of tumor necrosis factor production | regulation of leukocyte migration | phosphate-containing compound metabolic process | positive regulation of cellular extravasation | positive regulation of regulated secretory pathway | response to bacterium | positive regulation of anion channel activity | cell communication | regulation of cellular metabolic process | positive regulation of smooth muscle contraction | platelet activating factor receptor activity | signaling pattern recognition receptor activity | positive regulation of transporter activity | inflammatory response | positive regulation of inositol phosphate biosynthetic process | positive regulation of transcytosis | regulation of protein metabolic process | positive regulation of cell proliferation | regulation of locomotion | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | regulation of tube size | positive regulation of transport | regulation of phospholipase C activity | positive regulation of molecular function | cytokine production | activation of immune response | response to organic substance | regulation of innate immune response | lipopolysaccharide receptor activity | inositol trisphosphate metabolic process | regulation of exocytosis | cell surface receptor signaling pathway | regulation of vasoconstriction | metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of tube diameter | regulation of vesicle-mediated transport | regulation of secretion | positive regulation of interleukin-6 production | positive regulation of inorganic anion transmembrane transport | positive regulation of muscle contraction | organic substance metabolic process | positive regulation of ion transport | regulation of cell activation | positive regulation of leukocyte migration | regulation of phosphate metabolic process | regulation of ion transmembrane transport | positive regulation of cytokine production | regulation of regulated secretory pathway | positive regulation of phospholipase activity | positive regulation of carbohydrate metabolic process | signaling | regulation of transcription, DNA-templated | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | regulation of cytokine production | response to biotic stimulus | positive regulation of gastro-intestinal system smooth muscle contraction | regulation of ion transport | positive regulation of anion transport | purinergic nucleotide receptor activity | regulation of transport | regulation of cell-cell adhesion | positive regulation of interleukin-6 biosynthetic process | regulation of anion transport | positive regulation of metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of smooth muscle cell proliferation | positive regulation of cell motility | regulation of translation | regulation of interleukin-6 production | positive regulation of blood vessel diameter | chemotaxis | positive regulation of leukocyte cell-cell adhesion | inositol phosphate biosynthetic process | response to other organism | inositol phosphate metabolic process | signal transduction | positive regulation of gene expression | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | plasma membrane | cell periphery | membrane
