QuickView for PAM;jsessionid=58FF654D9BF50D8A20C1E646C85DD57D (gene)

Gene Symbol:

PAM Homo sapiens

Full name:

peptidylglycine alpha-amidating monooxygenase

Synonyms:

PAL, PHM, peptidyl-glycine alpha-amidating monooxygenase, pancreatic peptidylglycine alpha-amidating monooxygenase, peptidyl alpha-amidating enzyme, peptidyl-alpha-hydroxyglycine alpha-amidating lyase, peptidylamidoglycolate lyase, peptidylglycine 2-hydroxylase, peptidylglycine alpha-hydroxylating monooxygenase

Genomic Location:

Chr 5: 102229426-102393316

Description:

This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalyt...

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This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGCCAT_MIR183 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  OCT_Q6 ,  YGTCCTTGR_UNKNOWN ,  GCANCTGNY_MYOD_Q6 ,  CTTTGA_LEF1_Q2 ,  TCF4_Q5 ,  GGTGTGT_MIR329 ,  GCTTGAA_MIR498 ,  GTGCCTT_MIR506 ,  TTGTTT_FOXO4_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  ER_Q6_01 ,  CAGCTG_AP4_Q5 ,  ACAWYAAAG_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

5q21.1

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