QuickView for PAN2 (gene)
- Gene Symbol:
- PAN2
Homo sapiens - Full name:
- PAN2 poly(A) specific ribonuclease subunit
- Synonyms:
- USP52, PAN2-PAN3 deadenylation complex catalytic subunit PAN2, PAB-dependent poly(A)-specific ribonuclease subunit 2, PAB-dependent poly(A)-specific ribonuclease subunit PAN2, PAB1P-dependent poly(A)-nuclease, PAB1P-dependent poly(A)-specific ribonuclease, PABP-dependent poly(A) nuclease 2, PAN deadenylation complex catalytic subunit 2, PAN deadenylation complex subunit 2, PAN2 poly(A) specific ribonuclease subunit homolog, PAN2 polyA specific ribonuclease subunit, inactive ubiquitin carboxyl-terminal hydrolase 52, poly(A)-nuclease deadenylation complex subunit 2, ubiquitin specific peptidase 52, ubiquitin specific protease 52
- Genomic Location:
- Chr 12: 54996987-55014017
- Description:
-
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
PR_Q2 , GATTGGY_NFY_Q6_01 , VDR_Q3 , E2F1_Q4_01 , E2F4DP1_01 , AACTGGA_MIR145 , E2F_Q6_01 , NFKAPPAB_01 , ATGGYGGA_UNKNOWN , GATA1_04
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q13.3
GO Molecular Function
nuclease activity | 3'-5'-exoribonuclease activity | cation binding | poly(A)-specific ribonuclease activity | nucleic acid binding | exoribonuclease activity | hydrolase activity | ribonuclease activity | catalytic activity | hydrolase activity, acting on ester bonds | exoribonuclease activity, producing 5'-phosphomonoesters | ion binding | organic cyclic compound binding | protein binding | 3'-5' exonuclease activity | exonuclease activity | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | RNA processing | nuclease activity | 3'-5'-exoribonuclease activity | cellular process | organic substance catabolic process | poly(A)-specific ribonuclease activity | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | mRNA catabolic process | exoribonuclease activity | cellular nitrogen compound metabolic process | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | mRNA metabolic process | ribonuclease activity | nuclear-transcribed mRNA catabolic process | nucleobase-containing compound catabolic process | nitrogen compound metabolic process | regulation of gene expression | RNA catabolic process | nuclear-transcribed mRNA poly(A) tail shortening | exoribonuclease activity, producing 5'-phosphomonoesters | aromatic compound catabolic process | cellular macromolecule catabolic process | metabolic process | 3'-5' exonuclease activity | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of gene expression | RNA phosphodiester bond hydrolysis | gene expression | RNA phosphodiester bond hydrolysis, exonucleolytic | exonuclease activity | heterocycle metabolic process | cellular metabolic process | mRNA processing | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | ribonucleoprotein granule | cytoplasm | intracellular organelle | P-body | protein-containing complex | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | cytosol | intracellular | PAN complex
