QuickView for PAPC (gene)

Gene Symbol:

PCDH8 Homo sapiens

Full name:

protocadherin 8

Synonyms:

ARCADLIN, PAPC, protocadherin-8

Genomic Location:

Chr 13: 52316110-52320775

Description:

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon enc...

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This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ACAACCT_MIR453 ,  OCT1_05 ,  SMTTTTGT_UNKNOWN ,  GATA1_01 ,  OCT1_01 ,  AP3_Q6 ,  PR_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  SYATTGTG_UNKNOWN ,  CAGTGTT_MIR141_MIR200A ,  GTACTGT_MIR101 ,  STAT6_01 ,  HNF1_C ,  CTTTGA_LEF1_Q2 ,  GR_Q6_01 ,  OCT1_Q5_01 ,  OCT_C ,  TCF4_Q5 ,  TATAAA_TATA_01 ,  OCT1_Q6 ,  CEBPB_01 ,  DBP_Q6 ,  TGCAAAC_MIR452 ,  CEBP_01 ,  TTCYRGAA_UNKNOWN ,  GR_Q6 ,  TST1_01 ,  TGCCTTA_MIR124A ,  STAT5A_03 ,  GFI1_01 ,  GTGCCTT_MIR506 ,  TTGCCAA_MIR182 ,  POU3F2_02 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  ATATGCA_MIR448 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  GTTATAT_MIR410 ,  TATA_01 ,  WCAANNNYCAG_UNKNOWN ,  ER_Q6_01 ,  CDC5_01 ,  AACTTT_UNKNOWN ,  ACAWYAAAG_UNKNOWN ,  RYTAAWNNNTGAY_UNKNOWN ,  CCTNTMAGA_UNKNOWN ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-495

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Cytogenetic Map:

13q14.3

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