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QuickView for PAPPA2 (gene)

Gene Symbol:
PAPPA2 Homo sapiens Homo sapiens
Full name:
pappalysin 2
PAPP-A2, PAPP-E, PAPPE, PLAC3, pappalysin-2, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein E1
Genomic Location:
Chr 1: 174698930-175078595
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants.
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 1

GO Molecular Function

metallopeptidase activity | cation binding | metalloendopeptidase activity | hydrolase activity | catalytic activity | ion binding | zinc ion binding | transition metal ion binding | endopeptidase activity | metal ion binding | peptidase activity

GO Biological Process

metallopeptidase activity | proteolysis | bone development | cellular process | metalloendopeptidase activity | regulation of cellular process | response to stimulus | response to salt stress | response to stress | system development | nitrogen compound metabolic process | multicellular organism development | animal organ morphogenesis | response to osmotic stress | skeletal system morphogenesis | bone morphogenesis | protein metabolic process | regulation of growth | anatomical structure development | metabolic process | organic substance metabolic process | animal organ development | endopeptidase activity | cellular protein metabolic process | anatomical structure morphogenesis | developmental process | regulation of cell growth | skeletal system development | cellular metabolic process | peptidase activity | regulation of cellular component organization | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

apical plasma membrane | cell | cytoplasm | apical part of cell | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | cytosol | intracellular | membrane