QuickView for PBRM1 (gene)
- Gene Symbol:
- PBRM1
Homo sapiens - Full name:
- polybromo 1
- Synonyms:
- BAF180, PB1, protein polybromo-1, BRG1-associated factor 180, polybromo-1D
- Genomic Location:
- Chr 3: 52554423-52694892
- Description:
-
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
3p21.1
GO Molecular Function
nucleic acid binding | hydrolase activity | ATPase activity | pyrophosphatase activity | catalytic activity | chromatin binding | nucleoside-triphosphatase activity | ATPase activity, coupled | DNA binding | organic cyclic compound binding | protein binding | hydrolase activity, acting on acid anhydrides | DNA-dependent ATPase activity | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | DNA translocase activity
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | nucleosome organization | negative regulation of cellular process | cellular process | chromatin organization | protein-DNA complex disassembly | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cellular nitrogen compound metabolic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nucleosome disassembly | nitrogen compound metabolic process | ATP-dependent chromatin remodeling | regulation of gene expression | cell cycle | regulation of nitrogen compound metabolic process | biosynthetic process | aromatic compound biosynthetic process | transcription elongation from RNA polymerase II promoter | regulation of cellular metabolic process | chromatin remodeling | regulation of RNA metabolic process | chromatin assembly or disassembly | mitotic cell cycle | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | protein-containing complex disassembly | cellular macromolecule biosynthetic process | organelle organization | negative regulation of cell proliferation | heterocycle metabolic process | chromosome organization | cellular metabolic process | macromolecule metabolic process | DNA-templated transcription, elongation
GO Cellular Component
chromosome | RSC-type complex | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | intracellular organelle | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | SWI/SNF superfamily-type complex | membrane-enclosed lumen | nuclear chromatin | ATPase complex | intracellular
