QuickView for PC6 (gene)

Gene Symbol:

PCSK5 Homo sapiens

Full name:

proprotein convertase subtilisin/kexin type 5

Synonyms:

PC5, PC6, PC6A, SPC6, proprotein convertase subtilisin/kexin type 5, prohormone convertase 5, proprotein convertase 6, protease PC6, subtilase, subtilisin/kexin-like protease PC5

Genomic Location:

Chr 9: 77695441-77998164

Description:

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits ...

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This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  PU1_Q6 ,  YATTNATC_UNKNOWN ,  TGACCTY_ERR1_Q2 ,  OSF2_Q6 ,  GGGCGGR_SP1_Q6 ,  POU1F1_Q6 ,  RACCACAR_AML_Q6 ,  ELK1_01 ,  RGAGGAARY_PU1_Q6 ,  AACTTT_UNKNOWN ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-139

Cytogenetic Map:

9q21.13

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