QuickView for PCGF2 (gene)

Gene Symbol:

PCGF2 Homo sapiens

Full name:

polycomb group ring finger 2

Synonyms:

MEL-18, RNF110, ZNF144, polycomb group RING finger protein 2, DNA-binding protein Mel-18, ring finger protein 110, zinc finger protein 144

Genomic Location:

Chr 17: 34143676-34158084

Description:

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator o...

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The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  VDR_Q6 ,  ATGTACA_MIR493 ,  CTTTGTA_MIR524 ,  ATAGGAA_MIR202 ,  TFIII_Q6 ,  CDP_02 ,  SP1_Q4_01 ,  CDPCR1_01 ,  CATRRAGC_UNKNOWN ,  CCCNNGGGAR_OLF1_01 ,  SP1_Q6 ,  GTGCCTT_MIR506 ,  ZIC2_01 ,  CTTTGT_LEF1_Q2 ,  SP1_Q6_01 ,  SP1_Q2_01 ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

17q12

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