QuickView for PCK1;jsessionid=A4FBDCE906E8D5941D93B815B04DCAF8 (gene)

Gene Symbol:

PCK1 Homo sapiens

Full name:

phosphoenolpyruvate carboxykinase 1

Synonyms:

PCKDC, PEPCK-C, PEPCK1, PEPCKC, phosphoenolpyruvate carboxykinase, cytosolic [GTP], PEP carboxykinase, phosphoenolpyruvate carboxykinase 1 (soluble), phosphoenolpyruvate carboxykinase, cytosolic, phosphoenolpyruvate carboxylase, phosphopyruvate carboxylase

Genomic Location:

Chr 20: 55569543-55574922

Description:

This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects ...

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This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  GATA1_03 ,  TTANTCA_UNKNOWN ,  CREB_Q4_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  TACTTGA_MIR26A_MIR26B ,  HNF4_01 ,  CAGGTG_E12_Q6 ,  YCATTAA_UNKNOWN ,  ATF1_Q6 ,  IK2_01 ,  RYTAAWNNNTGAY_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-26

Cytogenetic Map:

20q13.31

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