QuickView for PCK2;jsessionid=FF2AF02F572D622E1C3FF468D3C97815 (gene)

Gene Symbol:

PCK2 Homo sapiens

Full name:

phosphoenolpyruvate carboxykinase 2, mitochondrial

Synonyms:

PEPCK, PEPCK-M, PEPCK2, phosphoenolpyruvate carboxykinase [GTP], mitochondrial, PEP carboxykinase, phosphopyruvate carboxylase

Genomic Location:

Chr 14: 23633323-23643179

Description:

This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described.

This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E4BP4_01 ,  CTTTGA_LEF1_Q2 ,  GGGCGGR_SP1_Q6 ,  AACTTT_UNKNOWN

Cytogenetic Map:

14q11.2-q12

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