protein self-association | sodium channel inhibitor activity | low-density lipoprotein particle receptor binding | channel regulator activity | nucleic acid binding | protein-containing complex binding | sodium channel regulator activity | lipoprotein particle receptor binding | receptor inhibitor activity | ion channel inhibitor activity | signaling receptor binding | hydrolase activity | molecular function regulator | catalytic activity | lipoprotein particle binding | channel inhibitor activity | serine hydrolase activity | organic cyclic compound binding | very-low-density lipoprotein particle binding | apolipoprotein receptor binding | low-density lipoprotein particle binding | apolipoprotein binding | protein binding | receptor regulator activity | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | very-low-density lipoprotein particle receptor binding | heterocyclic compound binding | peptidase activity | RNA binding
negative regulation of signaling receptor activity | response to extracellular stimulus | negative regulation of intracellular transport | response to nutrient levels | positive regulation of cellular component organization | regulation of sodium ion transmembrane transporter activity | regulation of cellular localization | regulation of cholesterol transport | positive regulation of apoptotic process | proteolysis | regulation of localization | sodium channel inhibitor activity | regulation of programmed cell death | regulation of sodium ion transport | establishment of localization | response to hormone | negative regulation of cellular process | protein processing | cell differentiation | regulation of intracellular cholesterol transport | nervous system development | cellular response to extracellular stimulus | positive regulation of protein catabolic process | neurogenesis | generation of neurons | phospholipid metabolic process | regulation of lipid transport | regulation of neuron death | sterol metabolic process | cellular process | organic substance catabolic process | channel regulator activity | localization | negative regulation of receptor-mediated endocytosis | regulation of sodium ion transmembrane transport | negative regulation of signaling | triglyceride metabolic process | cellular response to starvation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | regulation of binding | regulation of cellular process | sodium channel regulator activity | regulation of apoptotic process | regulation of metabolic process | catabolic process | hepaticobiliary system development | regulation of intracellular lipid transport | low-density lipoprotein receptor particle metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | negative regulation of receptor binding | receptor inhibitor activity | cellular lipid metabolic process | urogenital system development | negative regulation of low-density lipoprotein particle receptor binding | positive regulation of cellular protein catabolic process | response to stimulus | lysosomal transport | ion channel inhibitor activity | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | regulation of receptor internalization | vacuolar transport | alcohol metabolic process | regulation of plasma lipoprotein particle levels | sterol homeostasis | response to peptide | cholesterol homeostasis | response to starvation | negative regulation of low-density lipoprotein particle clearance | programmed cell death | negative regulation of receptor recycling | positive regulation of receptor catabolic process | negative regulation of transporter activity | cellular protein catabolic process | negative regulation of transport | negative regulation of metabolic process | protein modification process | kidney development | macromolecule modification | negative regulation of transmembrane transport | regulation of intracellular transport | molecular function regulator | organic hydroxy compound metabolic process | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | positive regulation of low-density lipoprotein particle receptor catabolic process | system development | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | channel inhibitor activity | multicellular organism development | cellular response to peptide hormone stimulus | phosphorus metabolic process | cellular response to insulin stimulus | lipid metabolic process | negative regulation of sodium ion transmembrane transporter activity | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | cellular response to stress | cellular response to peptide | protein catabolic process | organophosphate metabolic process | positive regulation of cellular metabolic process | liver development | regulation of nitrogen compound metabolic process | small molecule metabolic process | negative regulation of binding | negative regulation of ion transmembrane transport | regulation of cellular protein metabolic process | negative regulation of ion transport | positive regulation of neuron death | protein maturation | plasma lipoprotein particle clearance | phosphate-containing compound metabolic process | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of neuron apoptotic process | lipoprotein metabolic process | regulation of protein metabolic process | homeostatic process | glycerolipid metabolic process | renal system development | positive regulation of transport | neuron differentiation | regulation of signaling receptor activity | negative regulation of lipid transport | receptor regulator activity | protein metabolic process | response to organic substance | gland development | receptor catabolic process | neutral lipid metabolic process | cellular macromolecule catabolic process | positive regulation of neuron apoptotic process | response to insulin | anatomical structure development | negative regulation of endocytosis | metabolic process | regulation of protein catabolic process | cholesterol metabolic process | negative regulation of low-density lipoprotein receptor activity | regulation of vesicle-mediated transport | chemical homeostasis | positive regulation of cell death | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | cell death | animal organ development | gene expression | regulation of low-density lipoprotein particle receptor catabolic process | negative regulation of sodium ion transmembrane transport | positive regulation of programmed cell death | serine-type endopeptidase activity | regulation of ion transmembrane transport | serine-type peptidase activity | negative regulation of cholesterol transport | protein autoprocessing | organonitrogen compound catabolic process | steroid metabolic process | negative regulation of receptor-mediated endocytosis involved in cholesterol transport | regulation of cell communication | negative regulation of molecular function | regulation of protein binding | endopeptidase activity | regulation of endocytosis | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | cellular protein metabolic process | positive regulation of receptor internalization | regulation of ion transport | developmental process | cellular protein modification process | regulation of transport | regulation of receptor recycling | receptor metabolic process | response to organonitrogen compound | regulation of low-density lipoprotein particle clearance | positive regulation of metabolic process | negative regulation of sodium ion transport | cellular metabolic process | peptidase activity | cellular response to organic substance | regulation of cell death | low-density lipoprotein particle clearance | acylglycerol metabolic process | low-density lipoprotein particle receptor catabolic process | positive regulation of endocytosis | lipid homeostasis | regulation of cellular component organization | regulation of signaling | post-translational protein modification | macromolecule metabolic process | multicellular organismal process
endolysosome | intracellular membrane-bounded organelle | late endosome | extrinsic component of membrane | organelle membrane | cytoplasmic vesicle | cell | COPII-coated ER to Golgi transport vesicle | extrinsic component of plasma membrane | external side of plasma membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | endosome membrane | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | Golgi-associated vesicle | vacuole | vesicle | endoplasmic reticulum lumen | perinuclear region of cytoplasm | lytic vacuole | endosome | extracellular region | membrane-bounded organelle | organelle | PCSK9-LDLR complex | lysosome | extracellular space | cell periphery | extrinsic component of external side of plasma membrane | membrane-enclosed lumen | early endosome | endolysosome membrane | PCSK9-AnxA2 complex | rough endoplasmic reticulum | intracellular vesicle | cell surface | intracellular | lysosomal membrane | membrane | vacuolar membrane | coated vesicle