QuickView for PDE1A (gene)
- Gene Symbol:
- PDE1A
Homo sapiens - Full name:
- phosphodiesterase 1A
- Synonyms:
- CAM-PDE-1A, HCAM-1, HCAM1, HSPDE1A, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, 61 kDa Cam-PDE, calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase, cam-PDE 1A, phosphodiesterase 1A, calmodulin-dependent
- Genomic Location:
- Chr 2: 182715428-183095710
- Description:
-
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) t...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
2q32.1
GO Molecular Function
cation binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | cyclic-nucleotide phosphodiesterase activity | catalytic activity | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity | hydrolase activity, acting on ester bonds | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | calmodulin binding | metal ion binding | 3',5'-cyclic-nucleotide phosphodiesterase activity
GO Biological Process
purine ribonucleotide metabolic process | nucleoside phosphate catabolic process | regulation of programmed cell death | organophosphate catabolic process | cellular process | organic substance catabolic process | nucleotide metabolic process | carbohydrate derivative catabolic process | ribose phosphate metabolic process | ribonucleotide metabolic process | regulation of cellular process | regulation of apoptotic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | purine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cellular nitrogen compound metabolic process | G-protein coupled receptor signaling pathway | cellular biosynthetic process | nucleobase-containing compound catabolic process | nitrogen compound metabolic process | phosphorus metabolic process | cyclic nucleotide metabolic process | organophosphate metabolic process | small molecule metabolic process | cGMP metabolic process | regulation of smooth muscle cell apoptotic process | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | nucleotide catabolic process | phosphate-containing compound metabolic process | regulation of muscle cell apoptotic process | cell communication | aromatic compound catabolic process | cyclic nucleotide catabolic process | cGMP catabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | organonitrogen compound catabolic process | signaling | carbohydrate derivative metabolic process | heterocycle metabolic process | purine ribonucleotide catabolic process | cellular metabolic process | regulation of cell death | regulation of smooth muscle cell proliferation | signal transduction | purine nucleotide catabolic process
GO Cellular Component
intracellular membrane-bounded organelle | somatodendritic compartment | cell body | cell | neuronal cell body | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular
