QuickView for PDE1B (gene)

Gene Symbol:

PDE1B Homo sapiens

Full name:

phosphodiesterase 1B

Synonyms:

HEL-S-79p, PDE1B1, PDES1B, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, 63 kDa Cam-PDE, calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase, calmodulin-stimulated phosphodiesterase PDE1B1, cam-PDE 1B, epididymis secretory sperm binding protein Li 79p, phosphodiesterase 1B, calmodulin-dependent, presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B

Genomic Location:

Chr 12: 53229671-53259290

Description:

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP an...

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The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGANTCA_AP1_C ,  GCATTTG_MIR105 ,  COMP1_01 ,  CEBPDELTA_Q6 ,  NFE2_01 ,  CEBPB_01 ,  IRF7_01 ,  CTCCAAG_MIR432

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-149

Cytogenetic Map:

12q13.2

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