QuickView for PDE8A;jsessionid=07F539A4EF3EB49725BCB8C1946DC6FD (gene)
- Gene Symbol:
- PDE8A
Homo sapiens - Full name:
- phosphodiesterase 8A
- Synonyms:
- HsT19550, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, cAMP-specific cyclic nucleotide phosphodiesterase 8A
- Genomic Location:
- Chr 15: 83326209-83483377
- Description:
-
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in m...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
15q25.3
GO Molecular Function
kinase binding | cation binding | enzyme binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | cyclic-nucleotide phosphodiesterase activity | catalytic activity | hydrolase activity, acting on ester bonds | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | metal ion binding | 3',5'-cyclic-nucleotide phosphodiesterase activity
GO Biological Process
regulation of ERK1 and ERK2 cascade | purine ribonucleotide metabolic process | regulation of hydrogen peroxide-induced cell death | regulation of cellular response to oxidative stress | regulation of response to oxidative stress | nucleoside phosphate catabolic process | negative regulation of cellular response to oxidative stress | negative regulation of cellular process | organophosphate catabolic process | positive regulation of phosphate metabolic process | cellular process | organic substance catabolic process | nucleotide metabolic process | carbohydrate derivative catabolic process | ribose phosphate metabolic process | response to growth factor | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | negative regulation of oxidative stress-induced cell death | cellular aromatic compound metabolic process | negative regulation of response to drug | response to stimulus | purine nucleotide metabolic process | positive regulation of protein metabolic process | cellular nitrogen compound biosynthetic process | regulation of response to drug | cellular nitrogen compound metabolic process | G-protein coupled receptor signaling pathway | cellular biosynthetic process | nucleobase-containing compound catabolic process | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | nitrogen compound metabolic process | regulation of signal transduction | regulation of MAPK cascade | phosphorus metabolic process | cyclic nucleotide metabolic process | regulation of phosphorylation | regulation of gene expression | organophosphate metabolic process | negative regulation of hydrogen peroxide-induced cell death | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | small molecule metabolic process | positive regulation of intracellular signal transduction | cAMP catabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | nucleotide catabolic process | phosphate-containing compound metabolic process | regulation of cellular response to drug | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | regulation of protein phosphorylation | regulation of RNA metabolic process | cellular response to epidermal growth factor stimulus | cyclic nucleotide catabolic process | cAMP metabolic process | positive regulation of protein modification process | response to organic substance | regulation of response to reactive oxygen species | regulation of intracellular signal transduction | metabolic process | negative regulation of response to oxidative stress | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | positive regulation of MAPK cascade | response to epidermal growth factor | organonitrogen compound catabolic process | regulation of cell communication | signaling | regulation of transcription, DNA-templated | positive regulation of phosphorylation | carbohydrate derivative metabolic process | heterocycle metabolic process | positive regulation of metabolic process | purine ribonucleotide catabolic process | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | purine nucleotide catabolic process | cellular response to growth factor stimulus | regulation of phosphorus metabolic process
GO Cellular Component
cell | cytoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular
