QuickView for PDE8B (gene)

Gene Symbol:

PDE8B Homo sapiens

Full name:

phosphodiesterase 8B

Synonyms:

ADSD, PPNAD3, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, 3',5' cyclic nucleotide phosphodiesterase 8B, cell proliferation-inducing gene 22 protein

Genomic Location:

Chr 5: 76542462-76758999

Description:

The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encod...

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The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAGCCAT_MIR135A_MIR135B

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135

Cytogenetic Map:

5q13.3

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