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QuickView for PDE9A;jsessionid=5390CB75AB4603485EFFB00BBED4246E (gene)


Gene Symbol:
PDE9A Homo sapiens Homo sapiens
Full name:
phosphodiesterase 9A
Synonyms:
HSPDE9A2, high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, CGMP-specific 3',5'-cyclic phosphodiesterase type 9, phosphodiesterase PDE9A21
Genomic Location:
Chr 21: 42946931-43068688
Description:
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Bos taurus Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 21
21q22.3





GO Molecular Function

cation binding | hydrolase activity | cyclic-nucleotide phosphodiesterase activity | catalytic activity | hydrolase activity, acting on ester bonds | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | metal ion binding | 3',5'-cyclic-nucleotide phosphodiesterase activity

GO Biological Process

purine ribonucleotide metabolic process | regulation of muscle system process | nucleoside phosphate catabolic process | intracellular signal transduction | organophosphate catabolic process | cellular process | organic substance catabolic process | nucleotide metabolic process | carbohydrate derivative catabolic process | ribose phosphate metabolic process | ribonucleotide metabolic process | positive regulation of cardiac muscle hypertrophy | regulation of cellular process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | purine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | nucleobase-containing compound catabolic process | nitrogen compound metabolic process | cGMP-mediated signaling | phosphorus metabolic process | cyclic nucleotide metabolic process | organophosphate metabolic process | small molecule metabolic process | cGMP metabolic process | nucleobase-containing small molecule metabolic process | second-messenger-mediated signaling | biosynthetic process | aromatic compound biosynthetic process | nucleotide catabolic process | phosphate-containing compound metabolic process | cell communication | cyclic-nucleotide-mediated signaling | aromatic compound catabolic process | cyclic nucleotide catabolic process | regulation of cardiac muscle hypertrophy | cGMP catabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | organonitrogen compound catabolic process | signaling | carbohydrate derivative metabolic process | heterocycle metabolic process | purine ribonucleotide catabolic process | cellular metabolic process | signal transduction | purine nucleotide catabolic process

GO Cellular Component

intracellular membrane-bounded organelle | sarcolemma | ruffle | somatodendritic compartment | cell projection membrane | cell body | cell | neuronal cell body | ruffle membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | leading edge membrane | Golgi apparatus | cell projection | endomembrane system | plasma membrane | perikaryon | cell leading edge | perinuclear region of cytoplasm | membrane-bounded organelle | organelle | cell periphery | cytosol | intracellular | membrane