QuickView for PDHA1 (gene)
- Gene Symbol:
- PDHA1
Homo sapiens - Full name:
- pyruvate dehydrogenase E1 alpha 1 subunit
- Synonyms:
- PDHA, PDHAD, PDHCE1A, PHE1A, pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHE1-A type I, pyruvate dehydrogenase (lipoamide) alpha 1, pyruvate dehydrogenase E1 subunit, pyruvate dehydrogenase alpha 1, pyruvate dehydrogenase complex, E1-alpha polypeptide 1
- Genomic Location:
- Chr X: 19271972-19287886
- Description:
-
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate deh...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
Xp22.12
GO Molecular Function
pyruvate dehydrogenase activity | pyruvate dehydrogenase (acetyl-transferring) activity | catalytic activity | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | protein binding | pyruvate dehydrogenase (NAD+) activity | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | oxidoreductase activity
GO Biological Process
purine ribonucleotide metabolic process | tricarboxylic acid cycle | sulfur compound metabolic process | pyruvate dehydrogenase activity | glucose metabolic process | acetyl-CoA biosynthetic process | generation of precursor metabolites and energy | aerobic respiration | cellular process | nucleotide metabolic process | cellular respiration | ribose phosphate metabolic process | purine nucleotide biosynthetic process | pyruvate dehydrogenase (acetyl-transferring) activity | ribonucleotide metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | purine nucleotide metabolic process | monocarboxylic acid metabolic process | cellular nitrogen compound biosynthetic process | acetyl-CoA metabolic process | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cofactor metabolic process | cellular biosynthetic process | nucleotide biosynthetic process | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | nitrogen compound metabolic process | coenzyme biosynthetic process | antibiotic metabolic process | phosphorus metabolic process | acyl-CoA metabolic process | acetyl-CoA biosynthetic process from pyruvate | organophosphate metabolic process | cofactor biosynthetic process | monosaccharide metabolic process | small molecule metabolic process | cellular amide metabolic process | mitochondrial acetyl-CoA biosynthetic process from pyruvate | nucleobase-containing small molecule metabolic process | biosynthetic process | pyruvate metabolic process | aromatic compound biosynthetic process | purine ribonucleotide biosynthetic process | carbohydrate metabolic process | phosphate-containing compound metabolic process | drug metabolic process | carboxylic acid metabolic process | tricarboxylic acid metabolic process | metabolic process | hexose metabolic process | oxidation-reduction process | citrate metabolic process | pyruvate dehydrogenase (NAD+) activity | nucleobase-containing compound metabolic process | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | organic substance metabolic process | amide biosynthetic process | ribose phosphate biosynthetic process | organic acid metabolic process | energy derivation by oxidation of organic compounds | nicotinamide nucleotide metabolic process | carbohydrate derivative metabolic process | heterocycle metabolic process | cellular metabolic process | oxidoreductase activity
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | catalytic complex | cell | oxidoreductase complex | nuclear lumen | pyruvate dehydrogenase complex | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular | myelin sheath
